Genetic Diff erentiation in a Sample from Northern Mexico City Detected by HLA System Analysis: Impact in the Study of Population Immunogenetics

The major histocompatibility complex is directly involved in the immune response, and thus genes coding for its proteins are useful markers study of genetic diversity, susceptibility to disease (autoimmunity infections), transplant medicine, pharmacogenetics, among others. polymorphism system also allows researchers use it as a proxy population genetics analysis, such admixture structure. In order determine immunogenetic characteristics sample from northern part Mexico City them analyze diffferentiation other admixed populations, including those previous studies population, we analyzed molecular typing results donors patients Histocompatibility Laboratory Central Blood Bank Centro Médico Nacional La Raza selected according their geographic origin. HLA-A, -B, -DRB1, -DQB1 alleles were typed by polymerase chain reaction with sequence-specifijic primers. Allelic haplotype frequencies, well parameters, obtained maximum likelihood methods. most frequent haplotypes found HLA-A*02/-B*39/-DRB1*04/- DQB1*03:02P, HLA-A*02/-B*35/-DRB1*04/-DQB1*03:02P, HLA-A*68/-B*39/-DRB1*04/-DQB1*03:02P, HLA-A*02/-B*35/-DRB1*08/-DQB1*04. Importantly, second our (HLA-A*02/-B*35/-DRB1*04/-DQB1*03:02P) has not been previously reported any mixedancestry populations but commonly encountered Native American human groups, which can reflect impact migration dynamics conformation City, limitations regard diversity groups. Diffferences frequencies demonstrated that large urban conglomerates cannot be one homogeneous entity but, rather, should understood set structures social, political, economical factors influence genesis dynamics.